The diagnosis PCOS is identified by the presence of two or more symptoms, including irregular menstrual cycles, hyperandrogenism, and the formation of multiple cysts on the ovaries.  The problem is: do these medical people ever wonder why someone develops these conditions in connection with their cellular nutritional status?

However, do those who make the diagnoses wonder how someone develops it in the first place? PCOS, the most common endocrine pathology in females of reproductive age worldwide, was first described by Stein and Leventhal in 1935. Its prevalence varies between 5% and 15% depending on the diagnostic criteria used. According to specialty society guidelines, the diagnosis of PCOS requires the presence of at least two out of three criteria: chronic anovulation, hyperandrogenism (either clinical or biological), and polycystic ovaries.

It is important to exclude other disorders that mimic PCOS, such as thyroid disease, hyperprolactinemia, and non-classical congenital adrenal hyperplasia. Unfortunately, PCOS is often underdiagnosed, and it can take multiple visits to different physicians over a span of more than a year to receive a proper diagnosis. This can be incredibly frustrating for patients. Delay in diagnosis can also lead to the progression of comorbidities, making it even more challenging to implement lifestyle interventions that are crucial for managing PCOS symptoms and improving quality of life.

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Multiple morbidities are associated with PCOS, including infertility, metabolic syndrome, obesity, impaired glucose tolerance, type 2 diabetes mellitus (DM-2), cardiovascular risk, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis (NAFLD/NASH). There are different medical screening recommendations for each of these pathologies, but the clinician must have a low threshold for workup if any manifestation is shown in PCOS patients.

PCOS is not written in genetic stone: the epigenome strongly influences genes and what mostly what goes into your mouth determines this process

PCOS is a complex condition with multiple factors at play. Scientists have discovered several genes that are linked to the development of the disease. These genes are responsible for regulating different aspects of hormone production and the androgenic pathways in the body. Studies on twins have shown that around 70% of the risk for PCOS can be attributed to genetic factors. There are two widely accepted theories that suggest people with a genetic inclination, when exposed to specific environmental factors, may develop symptoms of PCOS. The primary environmental factors associated with this condition are obesity and insulin resistance.

Additionally, some theories propose that exposure to fetal androgens could also play a role. Two prevailing theories propose that individuals with a genetic predisposition may exhibit symptoms of PCOS when confronted with certain environmental factors. The key environmental factors linked to this condition are obesity and insulin resistance. Furthermore, there are theories suggesting that exposure to fetal androgens might also contribute to its development.

However, it's important to note that the environment also plays a crucial role in how these genes are expressed and how the disease progresses and this process has been termed "the epigenome" and it's heavily influenced by what your body absorbs.

Food supply and cultural changes have been linked to PCOS and increases in chronic metabolic dis-ease

Throughout the course of human history, the consumption of refined sugar was practically non-existent. However, this paradigm gradually shifted around 2,000 years ago when sugar cane was discovered. Nevertheless, it is within the past few centuries that we have witnessed a remarkable transformation in this aspect.

The 1920s witnessed a significant overhaul with the introduction of packaged and processed foods. In the past, the American diet primarily consisted of meat and potatoes, but it gradually expanded to include fruits, vegetables, and milk. As women gained more independence and autonomy, the popularity of prepared foods soared. TV and radio advertisements even embraced the slogan "less work for mother," emphasizing the convenience of prepared foods that required minimal time and effort.

Many of the processed and packaged foods that were introduced during this era have endured and are still prevalent today. Additionally, the 1920s marked the emergence of a new representation of womanhood centered around enjoyment and "liberation." However, while processed and packaged foods did contribute to freeing up women's time, the "liberated" lifestyle also introduced new beauty standards into society.

This is the confusing propaganda that misleads us all

There's no such thing as a "balanced diet" & nutrition isn't merely food. Why is that? It's because we're all individuals. Orthomolecular nutrition is the individualized analysis application of the substances within the food which our bodies often do not obtain enough of and are often blocked by antagonists.

Generalized Systems Cellular Nutritional Advice Often Lacking

Studies indicate that certain vitamins and minerals, including B-12, inositols, folate, vitamins D, E, and K, as well as minerals like calcium, zinc, selenium, and chromium picolinate, have shown potential benefits in managing PCOS. Moreover, vitamin-like nutrients such as bioflavonoids and α-lipoic acid have also been found to be advantageous.

Insulin resistance, a hormonal condition, has the potential to lead to weight gain, heart disease, and the development of type 2 diabetes if not properly managed. In addition, for women who have a genetic tendency to polycystic ovary syndrome (PCOS), excessive insulin levels can contribute to an overproduction of androgens, such as testosterone. Research suggests that insulin resistance plays a significant role in approximately 70-80% of PCOS cases.

Within the context of PCOS, the surplus of insulin prompts the ovaries to produce testosterone instead of estrogen. Consequently, this hormonal imbalance can give rise to frustrating symptoms like acne and alterations in hair growth. Moreover, insulin stimulates the brain to produce higher levels of luteinising hormone (LH), which can disrupt or delay ovulation, leading to irregular or absent menstrual periods. The primary cause of insulin resistance is often attributed to cellular fatigue resulting from prolonged exposure to elevated blood sugar glucose levels. This can occur due to excessive consumption of sugar or refined carbohydrates, such as bread, pasta, and baked goods.

Insulin resistance can manifest as a result of various factors including smoking combustibles, alcohol consumption, imbalanced gut bacteria and exposure to environmental toxins from food and elsewhere such as the workplace.

Because but not limited to these factors, it is plausible to develop insulin resistance even if one maintains a  what we think is a "well-balanced diet" but this concept never existed and never will because we're all individuals with unique bio-chemistry and often denatured and toxic food supplies and environment around us.

Insulin-resistant PCOS is primarily characterized by the buildup of weight in the abdominal area. To determine this, one can use a tape measure and ensure that the waist measurement is less than half of the person's height. If the waist measurement surpasses this limit, it suggests that insulin resistance is likely contributing to the development of PCOS. It's important to emphasize that being overweight is not a requirement for experiencing insulin resistance.

If you suspect any indication of PCOS or any other health issue its' adviseable to visit you medical doctor for a proper diagnosis and treatment plan as these are primarily the only legally allowable practitioners to diagnose and treat conditions a least in the western world.   It's important to remember that solely monitoring your blood glucose levels may not be enough, as you could still have insulin resistance even if your blood sugar levels seem normal.

Generalized advice to reduce that may also reverse PCOS

Generalized Cellular Nutritional Advice

Numerous studies have indicated that higher hormone levels, gut microbiome composition, and plasma metabolomics are novel factors associated with the different manifestations of PCOS . These clinical manifestations can vary throughout a person's lifetime, especially with weight gain, and can even coexist within the same individual. While personalized treatment remains the primary approach, categorizing these manifestations and following recommended therapies may also prove to be beneficial in a clinical setting.

It is crucial to implement precise recommendations well in advance of metabolic complications, particularly for women with PCOS who have a higher risk of developing endometrial and ovarian cancer . Therefore, incorporating anti-inflammatory remedies as a supplement to anticancer therapy becomes essential. These remedies can help deactivate the cascade of deteriorating signaling pathways, leading to improved survival rates, faster recovery, and an overall enhancement in the quality of life for patients.

Managing PCOS and alleviating its symptoms can be greatly supported by following a well-balanced diet plan. Research has shown that certain vitamins and minerals, such as B-12, inositols, folate, vitamins D, E, and K, as well as minerals like calcium, zinc, selenium, and chromium picolinate, can be beneficial for PCOS management. Moreover, vitamin-like nutrients such as bioflavonoids and α-lipoic acid can also provide assistance. In addition to these essential nutrients, a study on PCOS and nutrient supplementation has revealed that other formulations like melatonin, ω-3 fatty acids, probiotics, and cinnamon may have positive effects. Including these nutrients in your diet can help promote hormonal balance and contribute to overall well-being. 

Generalized Lifestyle Changes

Making lifestyle changes is crucial for safeguarding against PCOS and promoting overall well-being. Medical professionals and research suggest implementing positive adjustments in different areas of life, including steering clear of processed and unhealthy foods, engaging in regular physical activity, prioritizing mental well-being, and ensuring sufficient sleep. Embracing these modifications can greatly influence the management of PCOS symptoms.

Did you ever think about obtaining an inexpensive individualized assessment?

References:

PCOS NCBI

Impact of junk food on obesity and polycystic ovarian syndrome: Mechanisms and management strategies